Assay Detail
Binding
CHEMBL946982
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HDAC6
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Histone deacetylase inhibitors: from bench to clinic.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.06 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL272401 | — | — | 1 | 7.89 |
| CHEMBL403323 | — | — | 1 | 7.82 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 7.60 |
| CHEMBL402363 | AZUMAMIDE E | — | 1 | 4.92 |
| CHEMBL271102 | — | — | 1 | - |
| CHEMBL406800 | — | — | 1 | - |
| CHEMBL235842 | — | — | 1 | - |
| CHEMBL272980 | MOCETINOSTAT | 2.0 | 1 | - |
| CHEMBL27759 | ENTINOSTAT | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL272401 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL403323 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL402363 | AZUMAMIDE E | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL271102 | — | IC50 | - | — | - | |
| CHEMBL406800 | — | IC50 | - | — | - | |
| CHEMBL235842 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL272980 | MOCETINOSTAT | IC50 | > | 30000.0 | nM | - |
| CHEMBL27759 | ENTINOSTAT | IC50 | > | 100000.0 | nM | - |