Assay Detail
Binding
CHEMBL946993
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Inhibition of human HDAC8
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Histone deacetylase inhibitors: from bench to clinic.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.10 | 6.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL272613 | — | — | 1 | 6.72 |
| CHEMBL402451 | — | — | 1 | 6.16 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.09 |
| CHEMBL178727 | — | — | 1 | 5.41 |
| CHEMBL552879 | — | — | 1 | - |
| CHEMBL272612 | — | — | 1 | - |
| CHEMBL178150 | — | — | 1 | - |
| CHEMBL270962 | — | — | 1 | - |
| CHEMBL178726 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL272613 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL402451 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL178727 | — | IC50 | = | 3890.0 | nM | 5.41 |
| CHEMBL552879 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL272612 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL178150 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL270962 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL178726 | — | IC50 | > | 40000.0 | nM | - |