Assay Detail
Binding
CHEMBL947039
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]nisoxetine from human NET expressed in HEK293 cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent noradrenaline transporter (CHEMBL222) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis, in vitro characterization, and radiolabeling of reboxetine analogs as potential PET radioligands for imaging the norepinephrine transporter.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 8.93 | 9.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL181188 | — | — | 1 | 9.12 |
| CHEMBL223166 | — | — | 1 | 9.02 |
| CHEMBL411263 | — | — | 1 | 9.00 |
| CHEMBL411262 | — | — | 1 | 8.92 |
| CHEMBL272002 | — | — | 1 | 8.88 |
| CHEMBL270099 | — | — | 1 | 8.87 |
| CHEMBL272003 | — | — | 1 | 8.69 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL181188 | — | Ki | = | 0.76 | nM | 9.12 |
| CHEMBL223166 | — | Ki | = | 0.95 | nM | 9.02 |
| CHEMBL411263 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL411262 | — | Ki | = | 1.21 | nM | 8.92 |
| CHEMBL272002 | — | Ki | = | 1.32 | nM | 8.88 |
| CHEMBL270099 | — | Ki | = | 1.35 | nM | 8.87 |
| CHEMBL272003 | — | Ki | = | 2.06 | nM | 8.69 |