Assay Detail
Functional
CHEMBL947075
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at CCR3 receptor in cynomolgus monkey eosinophil assessed as as inhibition of chemotaxis
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Macaca fascicularis |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
C-C chemokine receptor type 3 (CHEMBL1075262) ↗| Type | SINGLE PROTEIN |
| Organism | Macaca fascicularis |
Publication
From rigid cyclic templates to conformationally stabilized acyclic scaffolds. Part I: the discovery of CCR3 antagonist development candidate BMS-639623 with picomolar inhibition potency against eosinophil chemotaxis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 9.82 | 9.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL399495 | — | — | 1 | 9.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL399495 | — | IC50 | = | 0.15 | nM | 9.82 |