Assay Detail

CHEMBL947208

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Binding

Binding affinity to rat bradykinin B1 receptor expressed in CHO cells

ChEMBL ↗

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Target

B1 bradykinin receptor (CHEMBL4613) ↗

Open DB target context

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B1 bradykinin receptor (CHEMBL4613) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target B1 bradykinin receptor

CHEMBL4613

Anchored from Assay target.

Protein identity B1 bradykinin receptor

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Rattus norvegicus
Cell Type	CHO
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

B1 bradykinin receptor (CHEMBL4613) ↗

Type	SINGLE PROTEIN
Organism	Rattus norvegicus

Publication

Alpha-hydroxy amides as a novel class of bradykinin B1 selective antagonists.

Wood MR, Schirripa KM, Kim JJ, Kuduk SD, Chang RK, Di Marco CN, DiPardo RM, Wan BL, Murphy KL, Ransom RW, Chang RS, Holahan MA, Cook JJ, Lemaire W, Mosser SD, Bednar RA, Tang C, Prueksaritanont T, Wallace AA, Mei Q, Yu J, Bohn DL, Clayton FC, Adarayn ED, Sitko GR, Leonard YM, Freidinger RM, Pettibone DJ, Bock MG.
Bioorg Med Chem Lett (2008) 18 : 716 -720
PubMed 18061443 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Ki	1	8.66	8.66

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL402831	—	—	1	8.66

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL402831	—	Ki	=	2.18	nM	8.66