Assay Detail
Binding
CHEMBL947299
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]TO901317 from human recombinant LXRbeta expressed in Escherichia coli by flashplate method
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Indazole-based liver X receptor (LXR) modulators with maintained atherosclerotic lesion reduction activity but diminished stimulation of hepatic triglyceride synthesis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 7.57 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL217118 | — | — | 1 | 8.70 |
| CHEMBL214719 | — | — | 1 | 8.70 |
| CHEMBL62136 | T091317 | — | 1 | 8.05 |
| CHEMBL517015 | — | — | 1 | 8.00 |
| CHEMBL59030 | — | — | 1 | 7.92 |
| CHEMBL456237 | LXR-623 | 1.0 | 1 | 7.62 |
| CHEMBL521398 | — | — | 1 | 7.52 |
| CHEMBL514428 | — | — | 1 | 7.50 |
| CHEMBL457977 | — | — | 1 | 7.48 |
| CHEMBL488173 | — | — | 1 | 7.42 |
| CHEMBL520883 | — | — | 1 | 7.42 |
| CHEMBL488174 | — | — | 1 | 7.40 |
| CHEMBL464189 | — | — | 1 | 7.39 |
| CHEMBL486955 | — | — | 1 | 7.32 |
| CHEMBL515852 | — | — | 1 | 7.31 |
| CHEMBL458597 | — | — | 1 | 7.24 |
| CHEMBL488802 | — | — | 1 | 5.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL217118 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL214719 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL62136 | T091317 | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL517015 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL59030 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL456237 | LXR-623 | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL521398 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL514428 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL457977 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL488173 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL520883 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL488174 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL464189 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL486955 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL515852 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL458597 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL488802 | — | IC50 | = | 1853.0 | nM | 5.73 |