Assay Detail
Binding
CHEMBL947432
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Inhibition of Akt2
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
RAC-beta serine/threonine-protein kinase (CHEMBL2431) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
The design and synthesis of potent and cell-active allosteric dual Akt 1 and 2 inhibitors devoid of hERG activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.77 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL443661 | — | — | 1 | 8.40 |
| CHEMBL488428 | — | — | 1 | 8.10 |
| CHEMBL446966 | — | — | 1 | 7.80 |
| CHEMBL444136 | — | — | 1 | 7.68 |
| CHEMBL446134 | — | — | 1 | 7.58 |
| CHEMBL502393 | — | — | 1 | 7.48 |
| CHEMBL447114 | — | — | 1 | 7.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL443661 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL488428 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL446966 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL444136 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL446134 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL502393 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL447114 | — | IC50 | = | 44.0 | nM | 7.36 |