Assay Detail
Binding
CHEMBL947458
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]nicotine from chick alpha4beta2 nAChR
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Gallus gallus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor subunit alpha-4 (CHEMBL5569) ↗| Type | SINGLE PROTEIN |
| Organism | Gallus gallus |
Publication
Potency and selectivity of trifluoroacetylimino and pyrazinoylimino nicotinic insecticides and their fit at a unique binding site niche.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.00 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL518310 | — | — | 1 | 6.30 |
| CHEMBL451432 | THIACLOPRID | — | 1 | 6.07 |
| CHEMBL494278 | — | — | 1 | 6.05 |
| CHEMBL406819 | IMIDACLOPRID | — | 1 | 5.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL518310 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL451432 | THIACLOPRID | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL494278 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL406819 | IMIDACLOPRID | IC50 | = | 2600.0 | nM | 5.58 |