Assay Detail
Binding
CHEMBL947922
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Inhibition of HDAC2
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Exploration of the internal cavity of histone deacetylase (HDAC) with selective HDAC1/HDAC2 inhibitors (SHI-1:2).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.37 | 7.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL235842 | — | — | 1 | 7.31 |
| CHEMBL269935 | — | — | 1 | 6.70 |
| CHEMBL271949 | — | — | 1 | 6.44 |
| CHEMBL437029 | — | — | 1 | 6.19 |
| CHEMBL271741 | — | — | 1 | 6.11 |
| CHEMBL405072 | — | — | 1 | 5.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL235842 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL269935 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL271949 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL437029 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL271741 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL405072 | — | IC50 | = | 3300.0 | nM | 5.48 |