Assay Detail
Binding
CHEMBL948034
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Inhibition of Akt3
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
RAC-gamma serine/threonine-protein kinase (CHEMBL4816) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Development of potent, allosteric dual Akt1 and Akt2 inhibitors with improved physical properties and cell activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.52 | 5.91 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL271091 | — | — | 1 | 5.91 |
| CHEMBL408151 | — | — | 1 | 5.79 |
| CHEMBL258844 | — | — | 1 | 5.66 |
| CHEMBL273160 | — | — | 1 | 5.50 |
| CHEMBL258696 | — | — | 1 | 5.14 |
| CHEMBL270444 | — | — | 1 | 5.13 |
| CHEMBL272292 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL271091 | — | IC50 | = | 1228.0 | nM | 5.91 |
| CHEMBL408151 | — | IC50 | = | 1613.0 | nM | 5.79 |
| CHEMBL258844 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL273160 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL258696 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL270444 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL272292 | — | IC50 | > | 50000.0 | nM | - |