Assay Detail
Binding
CHEMBL948194
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to human DAT
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent dopamine transporter (CHEMBL238) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and biological activity of piperazine and diazepane amides that are histamine H3 antagonists and serotonin reuptake inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 5.50 | 6.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL257738 | — | — | 1 | 6.48 |
| CHEMBL408206 | — | — | 1 | 6.48 |
| CHEMBL402644 | — | — | 1 | 6.31 |
| CHEMBL257909 | — | — | 1 | 6.11 |
| CHEMBL272699 | — | — | 1 | 5.60 |
| CHEMBL404247 | — | — | 1 | 5.52 |
| CHEMBL273157 | — | — | 1 | 5.40 |
| CHEMBL270607 | — | — | 1 | 5.16 |
| CHEMBL403148 | — | — | 1 | 5.16 |
| CHEMBL409877 | — | — | 1 | 5.16 |
| CHEMBL270625 | — | — | 1 | 5.14 |
| CHEMBL401683 | — | — | 1 | 5.14 |
| CHEMBL257221 | — | — | 1 | 5.11 |
| CHEMBL401867 | — | — | 1 | 5.10 |
| CHEMBL270165 | — | — | 1 | 5.08 |
| CHEMBL403377 | — | — | 1 | 5.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL257738 | — | Ki | = | 330.0 | nM | 6.48 |
| CHEMBL408206 | — | Ki | = | 330.0 | nM | 6.48 |
| CHEMBL402644 | — | Ki | = | 490.0 | nM | 6.31 |
| CHEMBL257909 | — | Ki | = | 770.0 | nM | 6.11 |
| CHEMBL272699 | — | Ki | = | 2500.0 | nM | 5.60 |
| CHEMBL404247 | — | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL273157 | — | Ki | = | 4000.0 | nM | 5.40 |
| CHEMBL270607 | — | Ki | = | 7000.0 | nM | 5.16 |
| CHEMBL403148 | — | Ki | = | 7000.0 | nM | 5.16 |
| CHEMBL409877 | — | Ki | = | 7000.0 | nM | 5.16 |
| CHEMBL270625 | — | Ki | = | 7300.0 | nM | 5.14 |
| CHEMBL401683 | — | Ki | = | 7300.0 | nM | 5.14 |
| CHEMBL257221 | — | Ki | = | 7700.0 | nM | 5.11 |
| CHEMBL401867 | — | Ki | = | 8000.0 | nM | 5.10 |
| CHEMBL270165 | — | Ki | = | 8300.0 | nM | 5.08 |
| CHEMBL403377 | — | Ki | = | 9000.0 | nM | 5.05 |