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Assay Detail

CHEMBL948205

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Growth inhibition of human U937 cells by [3H]thymidine incorporation assay
13
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type U-937
Confidence 1 — Organism
Curated By Autocuration

Target

U-937 (CHEMBL612794)
Type CELL-LINE
Organism Homo sapiens

Publication

Structural insights into hydroxycoumarin-induced apoptosis in U-937 cells.
Riveiro ME, Moglioni A, Vazquez R, Gomez N, Facorro G, Piehl L, de Celis ER, Shayo C, Davio C.
Bioorg Med Chem (2008) 16 : 2665 -2675
PubMed 18060791 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 4.41 4.50

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL244743 ESCULETIN 1 4.50
CHEMBL276618 4-METHYLDAPHNETIN 1 4.31
CHEMBL6466 COUMARIN 4.0 1 -
CHEMBL12208 HYMECROMONE 2.0 2 -
CHEMBL150372 3-HYDROXYCOUMARIN 1 -
CHEMBL12636 HYMECROMONE METHYL ETHER 1 -
CHEMBL270672 1 -
CHEMBL12626 1 -
CHEMBL406696 1 -
CHEMBL271915 1 -
CHEMBL406435 1 -
CHEMBL71851 SCOPOLETIN 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL244743 ESCULETIN IC50 = 31330.0 nM 4.50
CHEMBL276618 4-METHYLDAPHNETIN IC50 = 48650.0 nM 4.31
CHEMBL6466 COUMARIN IC50 > 2000000.0 nM -
CHEMBL12208 HYMECROMONE IC50 > 2000000.0 nM -
CHEMBL150372 3-HYDROXYCOUMARIN IC50 > 2000000.0 nM -
CHEMBL12636 HYMECROMONE METHYL ETHER IC50 > 2000000.0 nM -
CHEMBL270672 IC50 > 2000000.0 nM -
CHEMBL12626 IC50 = 627700.0 nM -
CHEMBL12208 HYMECROMONE IC50 = 710900.0 nM -
CHEMBL406696 IC50 > 2000000.0 nM -
CHEMBL271915 IC50 > 2000000.0 nM -
CHEMBL406435 IC50 > 2000000.0 nM -
CHEMBL71851 SCOPOLETIN IC50 = 151500.0 nM -