Assay Detail
Binding
CHEMBL948223
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Displacement of vitronectin from integrin alphavbeta3 receptor
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Design and synthesis of novel potent and selective integrin alphanubeta3 antagonists--novel synthetic routes to isoquinolinone, benzoxazinone, and quinazolinone acetates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 7.27 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL256672 | — | — | 1 | 9.15 |
| CHEMBL269950 | — | — | 1 | 8.82 |
| CHEMBL256673 | — | — | 1 | 8.38 |
| CHEMBL404371 | — | — | 1 | 8.36 |
| CHEMBL255952 | — | — | 1 | 8.13 |
| CHEMBL258325 | — | — | 1 | 8.00 |
| CHEMBL269961 | — | — | 1 | 7.96 |
| CHEMBL401660 | — | — | 1 | 7.89 |
| CHEMBL255741 | — | — | 1 | 7.57 |
| CHEMBL258327 | — | — | 1 | 7.43 |
| CHEMBL271284 | — | — | 1 | 7.30 |
| CHEMBL402115 | — | — | 1 | 7.30 |
| CHEMBL273168 | — | — | 1 | 6.91 |
| CHEMBL442705 | — | — | 1 | 6.30 |
| CHEMBL271486 | — | — | 1 | 6.00 |
| CHEMBL257730 | — | — | 1 | 5.30 |
| CHEMBL273169 | — | — | 1 | 5.00 |
| CHEMBL255789 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL256672 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL269950 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL256673 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL404371 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL255952 | — | IC50 | = | 7.4 | nM | 8.13 |
| CHEMBL258325 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL269961 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL401660 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL255741 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL258327 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL271284 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL402115 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL273168 | — | IC50 | = | 122.0 | nM | 6.91 |
| CHEMBL442705 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL271486 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL257730 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL273169 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL255789 | — | IC50 | = | 10000.0 | nM | 5.00 |