Assay Detail
Binding
CHEMBL948346
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Displacement of [3H]WIN-35428 from DAT
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Sodium-dependent dopamine transporter (CHEMBL238) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and monoamine transporter binding properties of 2beta-[3'-(substituted benzyl)isoxazol-5-yl]- and 2beta-[3'-methyl-4'-(substituted phenyl)isoxazol-5-yl]-3beta-(substituted phenyl)tropanes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 7.74 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL469887 | — | — | 1 | 8.80 |
| CHEMBL511466 | — | — | 1 | 8.73 |
| CHEMBL469888 | — | — | 1 | 8.41 |
| CHEMBL470690 | — | — | 1 | 8.39 |
| CHEMBL486041 | — | — | 1 | 8.23 |
| CHEMBL487874 | — | — | 1 | 8.21 |
| CHEMBL512878 | — | — | 1 | 8.19 |
| CHEMBL470903 | — | — | 1 | 8.19 |
| CHEMBL487873 | — | — | 1 | 8.16 |
| CHEMBL488423 | — | — | 1 | 8.07 |
| CHEMBL471696 | — | — | 1 | 8.06 |
| CHEMBL487875 | — | — | 1 | 8.02 |
| CHEMBL512685 | — | — | 1 | 7.89 |
| CHEMBL520035 | — | — | 1 | 7.76 |
| CHEMBL519910 | — | — | 1 | 7.66 |
| CHEMBL486042 | — | — | 1 | 7.65 |
| CHEMBL1790051 | — | — | 1 | 7.64 |
| CHEMBL469889 | — | — | 1 | 7.18 |
| CHEMBL471899 | — | — | 1 | 7.16 |
| CHEMBL471898 | — | — | 1 | 7.12 |
| CHEMBL470488 | — | — | 1 | 7.09 |
| CHEMBL529437 | COCAINE HYDROCHLORIDE | 4.0 | 1 | 7.05 |
| CHEMBL512189 | — | — | 1 | 6.96 |
| CHEMBL488422 | — | — | 1 | 6.92 |
| CHEMBL513206 | — | — | 1 | 6.87 |
| CHEMBL511288 | — | — | 1 | 6.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL469887 | — | IC50 | = | 1.57 | nM | 8.80 |
| CHEMBL511466 | — | IC50 | = | 1.86 | nM | 8.73 |
| CHEMBL469888 | — | IC50 | = | 3.93 | nM | 8.41 |
| CHEMBL470690 | — | IC50 | = | 4.09 | nM | 8.39 |
| CHEMBL486041 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL487874 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL512878 | — | IC50 | = | 6.42 | nM | 8.19 |
| CHEMBL470903 | — | IC50 | = | 6.45 | nM | 8.19 |
| CHEMBL487873 | — | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL488423 | — | IC50 | = | 8.6 | nM | 8.07 |
| CHEMBL471696 | — | IC50 | = | 8.74 | nM | 8.06 |
| CHEMBL487875 | — | IC50 | = | 9.6 | nM | 8.02 |
| CHEMBL512685 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL520035 | — | IC50 | = | 17.5 | nM | 7.76 |
| CHEMBL519910 | — | IC50 | = | 22.1 | nM | 7.66 |
| CHEMBL486042 | — | IC50 | = | 22.2 | nM | 7.65 |
| CHEMBL1790051 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL469889 | — | IC50 | = | 65.7 | nM | 7.18 |
| CHEMBL471899 | — | IC50 | = | 68.7 | nM | 7.16 |
| CHEMBL471898 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL470488 | — | IC50 | = | 81.6 | nM | 7.09 |
| CHEMBL529437 | COCAINE HYDROCHLORIDE | IC50 | = | 89.1 | nM | 7.05 |
| CHEMBL512189 | — | IC50 | = | 111.0 | nM | 6.96 |
| CHEMBL488422 | — | IC50 | = | 119.0 | nM | 6.92 |
| CHEMBL513206 | — | IC50 | = | 135.0 | nM | 6.87 |
| CHEMBL511288 | — | IC50 | = | 173.0 | nM | 6.76 |