Assay Detail
Binding
CHEMBL948347
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Displacement of [3H]nisoxetine from NET
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Sodium-dependent noradrenaline transporter (CHEMBL222) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and monoamine transporter binding properties of 2beta-[3'-(substituted benzyl)isoxazol-5-yl]- and 2beta-[3'-methyl-4'-(substituted phenyl)isoxazol-5-yl]-3beta-(substituted phenyl)tropanes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 26 | 6.21 | 6.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL487874 | — | — | 1 | 6.46 |
| CHEMBL471898 | — | — | 1 | 6.46 |
| CHEMBL487875 | — | — | 1 | 6.45 |
| CHEMBL488423 | — | — | 1 | 6.36 |
| CHEMBL469887 | — | — | 1 | 6.34 |
| CHEMBL469888 | — | — | 1 | 6.34 |
| CHEMBL486041 | — | — | 1 | 6.34 |
| CHEMBL512189 | — | — | 1 | 6.33 |
| CHEMBL469889 | — | — | 1 | 6.29 |
| CHEMBL511466 | — | — | 1 | 6.26 |
| CHEMBL470903 | — | — | 1 | 6.26 |
| CHEMBL1790051 | — | — | 1 | 6.25 |
| CHEMBL520035 | — | — | 1 | 6.17 |
| CHEMBL487873 | — | — | 1 | 6.11 |
| CHEMBL471899 | — | — | 1 | 6.10 |
| CHEMBL486042 | — | — | 1 | 6.08 |
| CHEMBL470690 | — | — | 1 | 5.99 |
| CHEMBL519910 | — | — | 1 | 5.96 |
| CHEMBL488422 | — | — | 1 | 5.89 |
| CHEMBL529437 | COCAINE HYDROCHLORIDE | 4.0 | 1 | 5.70 |
| CHEMBL470488 | — | — | 1 | - |
| CHEMBL511288 | — | — | 1 | - |
| CHEMBL513206 | — | — | 1 | - |
| CHEMBL512685 | — | — | 1 | - |
| CHEMBL471696 | — | — | 1 | - |
| CHEMBL512878 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL487874 | — | Ki | = | 347.0 | nM | 6.46 |
| CHEMBL471898 | — | Ki | = | 349.0 | nM | 6.46 |
| CHEMBL487875 | — | Ki | = | 357.0 | nM | 6.45 |
| CHEMBL488423 | — | Ki | = | 435.0 | nM | 6.36 |
| CHEMBL469887 | — | Ki | = | 454.0 | nM | 6.34 |
| CHEMBL469888 | — | Ki | = | 455.0 | nM | 6.34 |
| CHEMBL486041 | — | Ki | = | 454.0 | nM | 6.34 |
| CHEMBL512189 | — | Ki | = | 466.0 | nM | 6.33 |
| CHEMBL469889 | — | Ki | = | 519.0 | nM | 6.29 |
| CHEMBL511466 | — | Ki | = | 553.0 | nM | 6.26 |
| CHEMBL470903 | — | Ki | = | 552.0 | nM | 6.26 |
| CHEMBL1790051 | — | Ki | = | 556.0 | nM | 6.25 |
| CHEMBL520035 | — | Ki | = | 677.0 | nM | 6.17 |
| CHEMBL487873 | — | Ki | = | 770.0 | nM | 6.11 |
| CHEMBL471899 | — | Ki | = | 788.0 | nM | 6.10 |
| CHEMBL486042 | — | Ki | = | 840.0 | nM | 6.08 |
| CHEMBL470690 | — | Ki | = | 1030.0 | nM | 5.99 |
| CHEMBL519910 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL488422 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL529437 | COCAINE HYDROCHLORIDE | Ki | = | 1990.0 | nM | 5.70 |
| CHEMBL470488 | — | Ki | > | 2000.0 | nM | - |
| CHEMBL511288 | — | Ki | > | 2000.0 | nM | - |
| CHEMBL513206 | — | Ki | > | 2000.0 | nM | - |
| CHEMBL512685 | — | Ki | > | 2000.0 | nM | - |
| CHEMBL471696 | — | Ki | > | 2000.0 | nM | - |
| CHEMBL512878 | — | Ki | > | 2000.0 | nM | - |