Assay Detail
Binding
CHEMBL948355
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Inhibition of human KDR phosphorylation expressed in mouse NIH3T3 cells by ELISA
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | NIH3T3 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
7-Aminopyrazolo[1,5-a]pyrimidines as potent multitargeted receptor tyrosine kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 7.60 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL453057 | — | — | 1 | 9.15 |
| CHEMBL508928 | — | — | 1 | 9.00 |
| CHEMBL453578 | — | — | 1 | 8.15 |
| CHEMBL453058 | — | — | 1 | 8.10 |
| CHEMBL469467 | — | — | 1 | 7.77 |
| CHEMBL510814 | — | — | 1 | 7.68 |
| CHEMBL452522 | — | — | 1 | 7.66 |
| CHEMBL512839 | — | — | 1 | 7.55 |
| CHEMBL469456 | — | — | 1 | 7.54 |
| CHEMBL452783 | — | — | 1 | 7.48 |
| CHEMBL510788 | — | — | 1 | 7.46 |
| CHEMBL452288 | — | — | 1 | 7.31 |
| CHEMBL469455 | — | — | 1 | 7.26 |
| CHEMBL472302 | — | — | 1 | 7.16 |
| CHEMBL452284 | — | — | 1 | 7.16 |
| CHEMBL452287 | — | — | 1 | 7.07 |
| CHEMBL507533 | — | — | 1 | 6.66 |
| CHEMBL469468 | — | — | 1 | 6.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL453057 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL508928 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL453578 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL453058 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL469467 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL510814 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL452522 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL512839 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL469456 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL452783 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL510788 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL452288 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL469455 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL472302 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL452284 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL452287 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL507533 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL469468 | — | IC50 | = | 250.0 | nM | 6.60 |