Assay Detail
Functional
CHEMBL948511
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Cytotoxicity against mouse B16 cells after 48 hrs by MTT assay in presence of DFMO
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | B16 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of unsymmetrical polyamine derivatives as antitumor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.70 | 6.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL421884 | — | — | 1 | 6.01 |
| CHEMBL459038 | — | — | 1 | 5.99 |
| CHEMBL456879 | — | — | 1 | 5.88 |
| CHEMBL459213 | — | — | 1 | 5.70 |
| CHEMBL260932 | — | — | 1 | 5.57 |
| CHEMBL459037 | — | — | 1 | 5.57 |
| CHEMBL457053 | — | — | 1 | 5.56 |
| CHEMBL458150 | — | — | 1 | 5.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL421884 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL459038 | — | IC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL456879 | — | IC50 | = | 1310.0 | nM | 5.88 |
| CHEMBL459213 | — | IC50 | = | 1990.0 | nM | 5.70 |
| CHEMBL260932 | — | IC50 | = | 2690.0 | nM | 5.57 |
| CHEMBL459037 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL457053 | — | IC50 | = | 2730.0 | nM | 5.56 |
| CHEMBL458150 | — | IC50 | = | 4500.0 | nM | 5.35 |