Assay Detail
Binding
CHEMBL948526
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Binding affinity to GABAA alpha-1-beta-3-gamma-2 receptor
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
GABA-A receptor; alpha-1/beta-3/gamma-2 (CHEMBL2094121) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Selective influence on contextual memory: physiochemical properties associated with selectivity of benzodiazepine ligands at GABAA receptors containing the alpha5 subunit.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 6.68 | 8.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL415290 | Ro-151310 | — | 1 | 8.17 |
| CHEMBL458319 | — | — | 1 | 7.79 |
| CHEMBL458147 | — | — | 1 | 7.76 |
| CHEMBL58757 | — | — | 1 | 7.57 |
| CHEMBL471978 | — | — | 1 | 7.55 |
| CHEMBL471977 | — | — | 1 | 6.71 |
| CHEMBL458321 | — | — | 1 | 6.39 |
| CHEMBL461511 | — | — | 1 | 6.30 |
| CHEMBL459031 | — | — | 1 | 6.30 |
| CHEMBL45346 | — | — | 1 | 6.04 |
| CHEMBL511685 | — | — | 1 | 5.80 |
| CHEMBL471115 | — | — | 1 | 5.69 |
| CHEMBL458320 | — | — | 1 | 4.76 |
| CHEMBL510963 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL415290 | Ro-151310 | Ki | = | 6.8 | nM | 8.17 |
| CHEMBL458319 | — | Ki | = | 16.4 | nM | 7.79 |
| CHEMBL458147 | — | Ki | = | 17.3 | nM | 7.76 |
| CHEMBL58757 | — | Ki | = | 26.9 | nM | 7.57 |
| CHEMBL471978 | — | Ki | = | 28.4 | nM | 7.55 |
| CHEMBL471977 | — | Ki | = | 197.0 | nM | 6.71 |
| CHEMBL458321 | — | Ki | = | 408.0 | nM | 6.39 |
| CHEMBL461511 | — | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL459031 | — | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL45346 | — | Ki | = | 920.0 | nM | 6.04 |
| CHEMBL511685 | — | Ki | = | 1580.0 | nM | 5.80 |
| CHEMBL471115 | — | Ki | = | 2050.0 | nM | 5.69 |
| CHEMBL458320 | — | Ki | = | 17500.0 | nM | 4.76 |
| CHEMBL510963 | — | Ki | > | 300.0 | nM | - |