Assay Detail
Binding
CHEMBL948527
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to GABAA alpha-5-beta-3-gamma-2 receptor
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
GABA-A receptor; alpha-5/beta-3/gamma-2 (CHEMBL2094122) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Selective influence on contextual memory: physiochemical properties associated with selectivity of benzodiazepine ligands at GABAA receptors containing the alpha5 subunit.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 8.40 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL58757 | — | — | 1 | 9.40 |
| CHEMBL471978 | — | — | 1 | 8.78 |
| CHEMBL471977 | — | — | 1 | 8.58 |
| CHEMBL394710 | — | — | 1 | 7.82 |
| CHEMBL45346 | — | — | 1 | 7.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL58757 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL471978 | — | Ki | = | 1.68 | nM | 8.78 |
| CHEMBL471977 | — | Ki | = | 2.61 | nM | 8.58 |
| CHEMBL394710 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL45346 | — | Ki | = | 39.0 | nM | 7.41 |