Assay Detail
Binding
CHEMBL948897
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]NA uptake at human NA transporter expressed in HEK293 cells
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent noradrenaline transporter (CHEMBL222) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
1-(2-Phenoxyphenyl)methanamines: SAR for dual serotonin/noradrenaline reuptake inhibition, metabolic stability and hERG affinity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 7.40 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL247733 | — | — | 1 | 8.15 |
| CHEMBL403090 | — | — | 1 | 7.96 |
| CHEMBL402057 | — | — | 1 | 7.96 |
| CHEMBL404258 | — | — | 1 | 7.85 |
| CHEMBL402851 | — | — | 1 | 7.82 |
| CHEMBL403441 | — | — | 1 | 7.80 |
| CHEMBL272493 | — | — | 1 | 7.77 |
| CHEMBL438889 | — | — | 1 | 7.77 |
| CHEMBL256819 | — | — | 1 | 7.68 |
| CHEMBL403071 | — | — | 1 | 7.66 |
| CHEMBL258060 | — | — | 1 | 7.60 |
| CHEMBL404317 | — | — | 1 | 7.58 |
| CHEMBL402345 | — | — | 1 | 7.50 |
| CHEMBL258062 | — | — | 1 | 7.48 |
| CHEMBL404754 | — | — | 1 | 7.42 |
| CHEMBL256816 | — | — | 1 | 7.38 |
| CHEMBL401819 | — | — | 1 | 7.34 |
| CHEMBL256817 | — | — | 1 | 7.34 |
| CHEMBL401877 | — | — | 1 | 7.21 |
| CHEMBL256058 | — | — | 1 | 7.16 |
| CHEMBL256818 | — | — | 1 | 7.11 |
| CHEMBL257481 | — | — | 1 | 7.11 |
| CHEMBL257424 | — | — | 1 | 7.09 |
| CHEMBL258271 | — | — | 1 | 7.08 |
| CHEMBL255957 | — | — | 1 | 6.80 |
| CHEMBL257423 | — | — | 1 | 6.59 |
| CHEMBL256168 | — | — | 1 | 6.52 |
| CHEMBL407815 | — | — | 1 | 6.37 |
| CHEMBL258063 | — | — | 1 | - |
| CHEMBL401878 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL247733 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL403090 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL402057 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL404258 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL402851 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL403441 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL272493 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL438889 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL256819 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL403071 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL258060 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL404317 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL402345 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL258062 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL404754 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL256816 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL401819 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL256817 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL401877 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL256058 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL256818 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL257481 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL257424 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL258271 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL255957 | — | IC50 | = | 157.0 | nM | 6.80 |
| CHEMBL257423 | — | IC50 | = | 256.0 | nM | 6.59 |
| CHEMBL256168 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL407815 | — | IC50 | = | 429.0 | nM | 6.37 |
| CHEMBL258063 | — | IC50 | > | 400.0 | nM | - |
| CHEMBL401878 | — | IC50 | > | 400.0 | nM | - |