Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL948932

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of factor 12a
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Coagulation factor XII (CHEMBL2821)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Inhibitors of proteases and amide hydrolases that employ an alpha-ketoheterocycle as a key enabling functionality.
Maryanoff BE, Costanzo MJ.
Bioorg Med Chem (2008) 16 : 1562 -1595
PubMed 18053726 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 7.30 7.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL414002 1 7.30

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL414002 IC50 = 50.0 nM 7.30