Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL948938

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human beta-tryptase
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Inhibitors of proteases and amide hydrolases that employ an alpha-ketoheterocycle as a key enabling functionality.
Maryanoff BE, Costanzo MJ.
Bioorg Med Chem (2008) 16 : 1562 -1595
PubMed 18053726 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 15 7.37 8.82

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL211357 1 8.82
CHEMBL214368 1 8.52
CHEMBL211561 1 8.30
CHEMBL270437 1 8.19
CHEMBL256892 1 8.00
CHEMBL402150 1 7.72
CHEMBL255983 1 7.64
CHEMBL403693 1 7.60
CHEMBL409922 1 7.48
CHEMBL404190 1 7.39
CHEMBL256273 1 6.75
CHEMBL255208 1 6.60
CHEMBL403775 1 6.42
CHEMBL255384 1 6.33
CHEMBL270434 1 4.85

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL211357 Ki = 1.5 nM 8.82
CHEMBL214368 Ki = 3.0 nM 8.52
CHEMBL211561 Ki = 5.0 nM 8.30
CHEMBL270437 Ki = 6.5 nM 8.19
CHEMBL256892 Ki = 10.0 nM 8.00
CHEMBL402150 Ki = 19.0 nM 7.72
CHEMBL255983 Ki = 23.0 nM 7.64
CHEMBL403693 Ki = 25.0 nM 7.60
CHEMBL409922 Ki = 33.0 nM 7.48
CHEMBL404190 Ki = 41.0 nM 7.39
CHEMBL256273 Ki = 180.0 nM 6.75
CHEMBL255208 Ki = 250.0 nM 6.60
CHEMBL403775 Ki = 380.0 nM 6.42
CHEMBL255384 Ki = 470.0 nM 6.33
CHEMBL270434 Ki = 14000.0 nM 4.85