Assay Detail
Binding
CHEMBL948989
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of KDR
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
N-(3-(phenylcarbamoyl)arylpyrimidine)-5-carboxamides as potent and selective inhibitors of Lck: structure, synthesis and SAR.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.25 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL385937 | — | — | 1 | 8.70 |
| CHEMBL257858 | — | — | 1 | 6.59 |
| CHEMBL270793 | — | — | 1 | 5.69 |
| CHEMBL269936 | — | — | 1 | 5.17 |
| CHEMBL271018 | — | — | 1 | 5.08 |
| CHEMBL255533 | — | — | 1 | - |
| CHEMBL255132 | — | — | 1 | - |
| CHEMBL255989 | — | — | 1 | - |
| CHEMBL271650 | — | — | 1 | - |
| CHEMBL408292 | — | — | 1 | - |
| CHEMBL271099 | — | — | 1 | - |
| CHEMBL271101 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL385937 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL257858 | — | IC50 | = | 255.0 | nM | 6.59 |
| CHEMBL270793 | — | IC50 | = | 2030.0 | nM | 5.69 |
| CHEMBL269936 | — | IC50 | = | 6679.0 | nM | 5.17 |
| CHEMBL271018 | — | IC50 | = | 8330.0 | nM | 5.08 |
| CHEMBL255533 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL255132 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL255989 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL271650 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL408292 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL271099 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL271101 | — | IC50 | > | 25000.0 | nM | - |