Assay Detail
Binding
CHEMBL949045
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Inhibition of human Cdc2/cyclin B-mediated histone H1 kinase phosphorylation in HT29 cells
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationships of soluble 8-substituted 4-(2-chlorophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as inhibitors of the Wee1 and Chk1 checkpoint kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.19 | 6.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL255427 | — | — | 1 | 6.64 |
| CHEMBL410261 | — | — | 1 | 6.29 |
| CHEMBL271715 | — | — | 1 | 6.28 |
| CHEMBL411662 | — | — | 1 | 6.19 |
| CHEMBL401776 | — | — | 1 | 6.12 |
| CHEMBL272946 | — | — | 1 | 6.11 |
| CHEMBL270021 | — | — | 1 | 6.07 |
| CHEMBL401746 | — | — | 1 | 6.06 |
| CHEMBL403679 | — | — | 1 | 5.91 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL255427 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL410261 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL271715 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL411662 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL401776 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL272946 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL270021 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL401746 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL403679 | — | IC50 | = | 1230.0 | nM | 5.91 |