Assay Detail
Binding
CHEMBL949046
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Inhibition of human Cdc2 kinase PY15 phosphorylation in HT29 cells by Western blot
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationships of soluble 8-substituted 4-(2-chlorophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as inhibitors of the Wee1 and Chk1 checkpoint kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.97 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL410261 | — | — | 1 | 8.00 |
| CHEMBL270021 | — | — | 1 | 7.52 |
| CHEMBL255427 | — | — | 1 | 7.52 |
| CHEMBL272946 | — | — | 1 | 6.70 |
| CHEMBL411662 | — | — | 1 | 6.60 |
| CHEMBL271715 | — | — | 1 | 6.60 |
| CHEMBL401776 | — | — | 1 | 6.60 |
| CHEMBL403679 | — | — | 1 | 6.60 |
| CHEMBL401746 | — | — | 1 | 6.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL410261 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL270021 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL255427 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL272946 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL411662 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL271715 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL401776 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL403679 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL401746 | — | IC50 | = | 250.0 | nM | 6.60 |