Assay Detail
Binding
CHEMBL949067
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Inhibition of human 11beta-HSD1
13
Total Activities
13
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
11-beta-hydroxysteroid dehydrogenase 1 (CHEMBL4235) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of novel inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 by docking and pharmacophore modeling.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.81 | 7.93 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL230006 | ENOXOLONE | 2.0 | 1 | 7.93 |
| CHEMBL403586 | — | — | 1 | 6.58 |
| CHEMBL401901 | — | — | 1 | 6.16 |
| CHEMBL255846 | — | — | 1 | 6.11 |
| CHEMBL255190 | — | — | 1 | 5.73 |
| CHEMBL269976 | — | — | 1 | 5.71 |
| CHEMBL271265 | — | — | 1 | 5.45 |
| CHEMBL271468 | — | — | 1 | 5.43 |
| CHEMBL404357 | — | — | 1 | 5.34 |
| CHEMBL258133 | — | — | 1 | 5.23 |
| CHEMBL256790 | — | — | 1 | 5.20 |
| CHEMBL269978 | — | — | 1 | 4.84 |
| CHEMBL255992 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL230006 | ENOXOLONE | IC50 | = | 11.78 | nM | 7.93 |
| CHEMBL403586 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL401901 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL255846 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL255190 | — | IC50 | = | 1850.0 | nM | 5.73 |
| CHEMBL269976 | — | IC50 | = | 1950.0 | nM | 5.71 |
| CHEMBL271265 | — | IC50 | = | 3570.0 | nM | 5.45 |
| CHEMBL271468 | — | IC50 | = | 3740.0 | nM | 5.43 |
| CHEMBL404357 | — | IC50 | = | 4580.0 | nM | 5.34 |
| CHEMBL258133 | — | IC50 | = | 5870.0 | nM | 5.23 |
| CHEMBL256790 | — | IC50 | = | 6280.0 | nM | 5.20 |
| CHEMBL269978 | — | IC50 | = | 14600.0 | nM | 4.84 |
| CHEMBL255992 | — | Activity | - | — | - |