Assay Detail
Binding
CHEMBL949068
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of mouse 11beta-HSD1
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
11-beta-hydroxysteroid dehydrogenase 1 (CHEMBL3910) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Discovery of novel inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 by docking and pharmacophore modeling.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.92 | 7.98 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL230006 | ENOXOLONE | 2.0 | 1 | 7.98 |
| CHEMBL401901 | — | — | 1 | 6.32 |
| CHEMBL271265 | — | — | 1 | 5.68 |
| CHEMBL257001 | — | — | 1 | 5.44 |
| CHEMBL255993 | — | — | 1 | 5.21 |
| CHEMBL270367 | — | — | 1 | 4.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL230006 | ENOXOLONE | IC50 | = | 10.58 | nM | 7.98 |
| CHEMBL401901 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL271265 | — | IC50 | = | 2090.0 | nM | 5.68 |
| CHEMBL257001 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL255993 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL270367 | — | IC50 | = | 12490.0 | nM | 4.90 |