Assay Detail
Binding
CHEMBL949071
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HCV 1b NS5B polymerase
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepatitis C virus subtype 1b |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda6-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 1: exploration of 7'-substitution of benzothiadiazine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 6.03 | 7.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL176058 | — | — | 1 | 7.50 |
| CHEMBL403170 | — | — | 1 | 7.21 |
| CHEMBL399631 | — | — | 1 | 7.16 |
| CHEMBL270643 | — | — | 1 | 7.04 |
| CHEMBL270641 | — | — | 1 | 7.00 |
| CHEMBL258342 | — | — | 1 | 6.64 |
| CHEMBL255954 | — | — | 1 | 6.54 |
| CHEMBL541914 | — | — | 1 | 6.47 |
| CHEMBL272745 | — | — | 1 | 6.47 |
| CHEMBL270370 | — | — | 1 | 6.43 |
| CHEMBL257470 | — | — | 1 | 6.24 |
| CHEMBL256373 | — | — | 1 | 6.24 |
| CHEMBL437589 | — | — | 1 | 6.15 |
| CHEMBL430224 | — | — | 1 | 5.96 |
| CHEMBL402743 | — | — | 1 | 5.89 |
| CHEMBL258138 | — | — | 1 | 5.81 |
| CHEMBL258139 | — | — | 1 | 5.80 |
| CHEMBL257082 | — | — | 1 | 5.68 |
| CHEMBL258059 | — | — | 1 | 5.60 |
| CHEMBL255195 | — | — | 1 | 5.47 |
| CHEMBL257261 | — | — | 1 | 5.42 |
| CHEMBL402129 | — | — | 1 | 5.28 |
| CHEMBL401773 | — | — | 1 | 5.20 |
| CHEMBL401705 | — | — | 1 | 5.14 |
| CHEMBL403203 | — | — | 1 | 5.10 |
| CHEMBL402413 | — | — | 1 | 4.96 |
| CHEMBL255134 | — | — | 1 | 4.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL176058 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL403170 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL399631 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL270643 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL270641 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL258342 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL255954 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL541914 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL272745 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL270370 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL257470 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL256373 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL437589 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL430224 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL402743 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL258138 | — | IC50 | = | 1550.0 | nM | 5.81 |
| CHEMBL258139 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL257082 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL258059 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL255195 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL257261 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL402129 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL401773 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL401705 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL403203 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL402413 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL255134 | — | IC50 | = | 33000.0 | nM | 4.48 |