Assay Detail
Functional
CHEMBL949072
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HCV 1b in Huh7/C24 cells after 72 hrs by replicon assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Cell Type | Huh7/C24 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda6-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 1: exploration of 7'-substitution of benzothiadiazine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 13 | 5.55 | 6.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL403170 | — | — | 1 | 6.68 |
| CHEMBL399631 | — | — | 1 | 6.39 |
| CHEMBL257470 | — | — | 1 | 6.27 |
| CHEMBL270643 | — | — | 1 | 6.15 |
| CHEMBL270641 | — | — | 1 | 5.96 |
| CHEMBL541914 | — | — | 1 | 5.68 |
| CHEMBL272745 | — | — | 1 | 5.19 |
| CHEMBL402743 | — | — | 1 | 5.15 |
| CHEMBL258138 | — | — | 1 | 5.12 |
| CHEMBL258139 | — | — | 1 | 5.09 |
| CHEMBL257261 | — | — | 1 | 4.58 |
| CHEMBL270370 | — | — | 1 | 4.28 |
| CHEMBL401773 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL403170 | — | EC50 | = | 210.0 | nM | 6.68 |
| CHEMBL399631 | — | EC50 | = | 410.0 | nM | 6.39 |
| CHEMBL257470 | — | EC50 | = | 540.0 | nM | 6.27 |
| CHEMBL270643 | — | EC50 | = | 710.0 | nM | 6.15 |
| CHEMBL270641 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL541914 | — | EC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL272745 | — | EC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL402743 | — | EC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL258138 | — | EC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL258139 | — | EC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL257261 | — | EC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL270370 | — | EC50 | = | 53000.0 | nM | 4.28 |
| CHEMBL401773 | — | EC50 | > | 10000.0 | nM | - |