Assay Detail
Functional
CHEMBL949097
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Inhibition of human HepG2 cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Histone deacetylase inhibitors: from bench to clinic.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 8.96 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 9.22 |
| CHEMBL272052 | — | — | 1 | 9.05 |
| CHEMBL407420 | — | — | 1 | 9.05 |
| CHEMBL27759 | ENTINOSTAT | 3.0 | 1 | 9.05 |
| CHEMBL272240 | — | — | 1 | 9.00 |
| CHEMBL260530 | — | — | 1 | 8.92 |
| CHEMBL260738 | — | — | 1 | 8.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL272052 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL407420 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL272240 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL260530 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL260738 | — | IC50 | = | 3.5 | nM | 8.46 |