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Assay Detail

CHEMBL949101

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of HDAC from human K562 cells
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type K562
Confidence 5 — Multiple protein complex / RNA
Curated By Autocuration

Target

Histone deacetylase (CHEMBL2093865)
Type PROTEIN FAMILY
Organism Homo sapiens

Publication

Histone deacetylase inhibitors: from bench to clinic.
Paris M, Porcelloni M, Binaschi M, Fattori D.
J Med Chem (2008) 51 : 1505 -1529
PubMed 18247554 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 38 7.48 8.68

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL123626 1 8.68
CHEMBL124282 1 8.60
CHEMBL339720 1 8.57
CHEMBL113033 1 8.51
CHEMBL112446 1 8.43
CHEMBL340885 1 8.37
CHEMBL435415 1 8.37
CHEMBL271800 1 8.37
CHEMBL123905 1 8.36
CHEMBL125042 1 8.24
CHEMBL124650 1 8.17
CHEMBL340835 1 8.07
CHEMBL324429 1 8.04
CHEMBL127846 1 8.01
CHEMBL126274 1 7.96
CHEMBL339796 1 7.92
CHEMBL127184 1 7.89
CHEMBL124909 1 7.72
CHEMBL114184 1 7.70
CHEMBL338776 1 7.64
CHEMBL126273 1 7.38
CHEMBL255714 AZUMAMIDE A 1 7.35
CHEMBL432618 1 7.21
CHEMBL123506 1 7.13
CHEMBL321689 1 7.09
CHEMBL124593 1 7.05
CHEMBL113303 1 6.96
CHEMBL432243 1 6.96
CHEMBL98 VORINOSTAT 4.0 1 6.85
CHEMBL257973 AZUMAMIDE D 1 5.89

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL123626 IC50 = 2.1 nM 8.68
CHEMBL124282 IC50 = 2.5 nM 8.60
CHEMBL339720 IC50 = 2.7 nM 8.57
CHEMBL113033 IC50 = 3.1 nM 8.51
CHEMBL112446 IC50 = 3.7 nM 8.43
CHEMBL340885 IC50 = 4.3 nM 8.37
CHEMBL435415 IC50 = 4.3 nM 8.37
CHEMBL271800 IC50 = 4.3 nM 8.37
CHEMBL123905 IC50 = 4.4 nM 8.36
CHEMBL125042 IC50 = 5.8 nM 8.24
CHEMBL124650 IC50 = 6.8 nM 8.17
CHEMBL340835 IC50 = 8.5 nM 8.07
CHEMBL324429 IC50 = 9.1 nM 8.04
CHEMBL127846 IC50 = 9.8 nM 8.01
CHEMBL126274 IC50 = 11.0 nM 7.96
CHEMBL339796 IC50 = 12.0 nM 7.92
CHEMBL127184 IC50 = 13.0 nM 7.89
CHEMBL124909 IC50 = 19.0 nM 7.72
CHEMBL114184 IC50 = 20.0 nM 7.70
CHEMBL338776 IC50 = 23.0 nM 7.64
CHEMBL126273 IC50 = 42.0 nM 7.38
CHEMBL255714 AZUMAMIDE A IC50 = 45.0 nM 7.35
CHEMBL432618 IC50 = 62.0 nM 7.21
CHEMBL123506 IC50 = 74.0 nM 7.13
CHEMBL321689 IC50 = 82.0 nM 7.09
CHEMBL124593 IC50 = 89.0 nM 7.05
CHEMBL113303 IC50 = 110.0 nM 6.96
CHEMBL432243 IC50 = 109.0 nM 6.96
CHEMBL98 VORINOSTAT IC50 = 140.0 nM 6.85
CHEMBL257973 AZUMAMIDE D IC50 = 1300.0 nM 5.89
CHEMBL112148 IC50 = 2900.0 nM 5.54
CHEMBL115049 IC50 = 3700.0 nM 5.43
CHEMBL321253 IC50 = 4900.0 nM 5.31
CHEMBL269817 IC50 = 27000.0 nM 4.57
CHEMBL113495 IC50 > 50000.0 nM -
CHEMBL113566 IC50 > 5000.0 nM -
CHEMBL265564 IC50 > 50000.0 nM -
CHEMBL113367 IC50 > 50000.0 nM -