Assay Detail
Binding
CHEMBL949106
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Inhibition of human liver HDAC
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Histone deacetylase inhibitors: from bench to clinic.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.83 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL203207 | — | — | 1 | 7.40 |
| CHEMBL201473 | — | — | 1 | 7.22 |
| CHEMBL371212 | — | — | 1 | 6.96 |
| CHEMBL203028 | — | — | 1 | 6.92 |
| CHEMBL198350 | — | — | 1 | 6.82 |
| CHEMBL201710 | — | — | 1 | 6.75 |
| CHEMBL200980 | — | — | 1 | 6.58 |
| CHEMBL201131 | — | — | 1 | 6.42 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL203207 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL201473 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL371212 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL203028 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL198350 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL201710 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL200980 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL201131 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 440.0 | nM | 6.36 |