Assay Detail
Binding
CHEMBL949107
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HDAC in human CEM cells
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Histone deacetylase inhibitors: from bench to clinic.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.48 | 6.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.48 |
| CHEMBL198350 | — | — | 1 | 5.89 |
| CHEMBL201131 | — | — | 1 | 5.80 |
| CHEMBL201710 | — | — | 1 | 5.65 |
| CHEMBL201473 | — | — | 1 | 5.13 |
| CHEMBL203028 | — | — | 1 | 5.03 |
| CHEMBL371212 | — | — | 1 | 5.03 |
| CHEMBL203207 | — | — | 1 | 4.81 |
| CHEMBL200980 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL198350 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL201131 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL201710 | — | IC50 | = | 2240.0 | nM | 5.65 |
| CHEMBL201473 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL203028 | — | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL371212 | — | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL203207 | — | IC50 | = | 15500.0 | nM | 4.81 |
| CHEMBL200980 | — | IC50 | > | 25000.0 | nM | - |