Assay Detail
Binding
CHEMBL949428
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human cloned ERG
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Candidate selection and preclinical evaluation of N-tert-butyl isoquine (GSK369796), an affordable and effective 4-aminoquinoline antimalarial for the 21st century.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.70 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1107 | HALOFANTRINE | 4.0 | 1 | 7.40 |
| CHEMBL1630 | — | — | 1 | 5.62 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 5.60 |
| CHEMBL147587 | ISOQUINE | — | 1 | 5.41 |
| CHEMBL147806 | GSK-369796 | 1.0 | 1 | 5.12 |
| CHEMBL1235 | DESETHYL AMODIAQUINE | — | 1 | 5.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1107 | HALOFANTRINE | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1630 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL147587 | ISOQUINE | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL147806 | GSK-369796 | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL1235 | DESETHYL AMODIAQUINE | IC50 | = | 9500.0 | nM | 5.02 |