Assay Detail
ADMET
CHEMBL949431
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant CYP2C8
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Candidate selection and preclinical evaluation of N-tert-butyl isoquine (GSK369796), an affordable and effective 4-aminoquinoline antimalarial for the 21st century.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.89 | 5.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1630 | — | — | 1 | 5.57 |
| CHEMBL147587 | ISOQUINE | — | 1 | 4.89 |
| CHEMBL1235 | DESETHYL AMODIAQUINE | — | 1 | 4.70 |
| CHEMBL147806 | GSK-369796 | 1.0 | 1 | 4.64 |
| CHEMBL146826 | DESETHYL ISOQUINE | — | 1 | 4.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1630 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL147587 | ISOQUINE | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL1235 | DESETHYL AMODIAQUINE | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL147806 | GSK-369796 | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL146826 | DESETHYL ISOQUINE | IC50 | = | 23000.0 | nM | 4.64 |