Assay Detail
Functional
CHEMBL949436
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 in human erythrocytes after 48 hrs by [3H]hypoxanthine uptake
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Candidate selection and preclinical evaluation of N-tert-butyl isoquine (GSK369796), an affordable and effective 4-aminoquinoline antimalarial for the 21st century.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.92 | 8.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL146826 | DESETHYL ISOQUINE | — | 1 | 8.04 |
| CHEMBL1630 | — | — | 1 | 7.95 |
| CHEMBL147806 | GSK-369796 | 1.0 | 1 | 7.95 |
| CHEMBL147587 | ISOQUINE | — | 1 | 7.94 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 7.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL146826 | DESETHYL ISOQUINE | IC50 | = | 9.2 | nM | 8.04 |
| CHEMBL1630 | — | IC50 | = | 11.2 | nM | 7.95 |
| CHEMBL147806 | GSK-369796 | IC50 | = | 11.2 | nM | 7.95 |
| CHEMBL147587 | ISOQUINE | IC50 | = | 11.6 | nM | 7.94 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 19.4 | nM | 7.71 |