Assay Detail
Binding
CHEMBL949940
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Inhibition of Trypanosoma cruzi prolyl endopeptidase Tc80
6
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Trypanosoma cruzi |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Inhibitors of proteases and amide hydrolases that employ an alpha-ketoheterocycle as a key enabling functionality.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 8.78 | 9.59 |
| IC50 | 1 | 6.70 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL269822 | — | — | 1 | 9.59 |
| CHEMBL318284 | — | — | 1 | 9.55 |
| CHEMBL273161 | — | — | 1 | 8.92 |
| CHEMBL97152 | — | — | 1 | 8.72 |
| CHEMBL99237 | — | — | 1 | 7.14 |
| CHEMBL257514 | — | — | 1 | 6.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL269822 | — | Ki | = | 0.26 | nM | 9.59 |
| CHEMBL318284 | — | Ki | = | 0.28 | nM | 9.55 |
| CHEMBL273161 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL97152 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL99237 | — | Ki | = | 72.0 | nM | 7.14 |
| CHEMBL257514 | — | IC50 | = | 200.0 | nM | 6.70 |