Assay Detail
Binding
CHEMBL949946
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human liver cathepsin B
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Inhibitors of proteases and amide hydrolases that employ an alpha-ketoheterocycle as a key enabling functionality.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 5.81 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL271004 | — | — | 1 | 8.70 |
| CHEMBL446718 | — | — | 1 | 7.05 |
| CHEMBL379622 | — | — | 1 | 7.03 |
| CHEMBL405602 | — | — | 1 | 7.01 |
| CHEMBL209215 | — | — | 1 | 6.66 |
| CHEMBL208566 | — | — | 1 | 5.96 |
| CHEMBL270792 | — | — | 1 | 5.68 |
| CHEMBL257692 | — | — | 1 | 5.16 |
| CHEMBL272374 | — | — | 1 | 4.80 |
| CHEMBL272375 | — | — | 1 | 4.60 |
| CHEMBL411498 | — | — | 1 | 4.47 |
| CHEMBL210198 | — | — | 1 | 4.24 |
| CHEMBL211050 | — | — | 1 | 4.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL271004 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL446718 | — | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL379622 | — | Ki | = | 93.0 | nM | 7.03 |
| CHEMBL405602 | — | Ki | = | 98.0 | nM | 7.01 |
| CHEMBL209215 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL208566 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL270792 | — | Ki | = | 2100.0 | nM | 5.68 |
| CHEMBL257692 | — | Ki | = | 7000.0 | nM | 5.16 |
| CHEMBL272374 | — | Ki | = | 16000.0 | nM | 4.80 |
| CHEMBL272375 | — | Ki | = | 25000.0 | nM | 4.60 |
| CHEMBL411498 | — | Ki | = | 34000.0 | nM | 4.47 |
| CHEMBL210198 | — | Ki | = | 57000.0 | nM | 4.24 |
| CHEMBL211050 | — | Ki | = | 73000.0 | nM | 4.14 |