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Assay Detail

CHEMBL949949

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibition of bovine bone resorption in rabbit osteoclasts
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Oryctolagus cuniculus
Cell Type Osteoclast
Confidence 1 — Organism
Curated By Autocuration

Target

Osteoclast (CHEMBL612548)
Type CELL-LINE

Publication

Inhibitors of proteases and amide hydrolases that employ an alpha-ketoheterocycle as a key enabling functionality.
Maryanoff BE, Costanzo MJ.
Bioorg Med Chem (2008) 16 : 1562 -1595
PubMed 18053726 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 6.89 6.89

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL209293 1 6.89

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL209293 IC50 = 130.0 nM 6.89