Assay Detail
Functional
CHEMBL950103
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human PPARgamma expressed in monkey CV1 cells by transactivation assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CV-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Peroxisome proliferator-activated receptor gamma (CHEMBL235) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of a novel class of 1,3-dioxane-2-carboxylic acid derivatives as subtype-selective peroxisome proliferator-activated receptor alpha (PPARalpha) agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 5.23 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL401811 | — | — | 1 | 6.52 |
| CHEMBL270835 | — | — | 1 | 6.52 |
| CHEMBL404439 | — | — | 1 | 6.00 |
| CHEMBL256013 | — | — | 1 | 5.52 |
| CHEMBL271873 | — | — | 1 | 5.00 |
| CHEMBL447533 | — | — | 1 | 5.00 |
| CHEMBL401712 | — | — | 1 | 4.52 |
| CHEMBL264374 | BEZAFIBRATE | 3.0 | 1 | 4.00 |
| CHEMBL401616 | — | — | 1 | 4.00 |
| CHEMBL981 | FENOFIBRIC ACID | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL401811 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL270835 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL404439 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL256013 | — | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL271873 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL447533 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL401712 | — | EC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL264374 | BEZAFIBRATE | EC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL401616 | — | EC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL981 | FENOFIBRIC ACID | EC50 | > | 100000.0 | nM | - |