Assay Detail
Functional
CHEMBL950104
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human PPARdelta expressed in monkey CV1 cells by transactivation assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CV-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Peroxisome proliferator-activated receptor delta (CHEMBL3979) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of a novel class of 1,3-dioxane-2-carboxylic acid derivatives as subtype-selective peroxisome proliferator-activated receptor alpha (PPARalpha) agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 4.52 | 4.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL401811 | — | — | 1 | 4.52 |
| CHEMBL264374 | BEZAFIBRATE | 3.0 | 1 | 4.52 |
| CHEMBL981 | FENOFIBRIC ACID | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL401811 | — | EC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL264374 | BEZAFIBRATE | EC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL981 | FENOFIBRIC ACID | EC50 | > | 100000.0 | nM | - |