Assay Detail
Binding
CHEMBL950125
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Inhibition of human HDAC in HeLa cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
New sulfurated derivatives of valproic acid with enhanced histone deacetylase inhibitory activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.10 | 6.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL402341 | — | — | 1 | 6.35 |
| CHEMBL271677 | — | — | 1 | 5.02 |
| CHEMBL257239 | — | — | 1 | 4.76 |
| CHEMBL272134 | — | — | 1 | 4.25 |
| CHEMBL109 | VALPROIC ACID | 4.0 | 1 | - |
| CHEMBL271256 | — | — | 1 | - |
| CHEMBL271923 | — | — | 1 | - |
| CHEMBL255609 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL402341 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL271677 | — | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL257239 | — | IC50 | = | 17500.0 | nM | 4.76 |
| CHEMBL272134 | — | IC50 | = | 56400.0 | nM | 4.25 |
| CHEMBL109 | VALPROIC ACID | IC50 | = | 995000.0 | nM | - |
| CHEMBL271256 | — | IC50 | = | 198000.0 | nM | - |
| CHEMBL271923 | — | IC50 | = | 102000.0 | nM | - |
| CHEMBL255609 | — | IC50 | > | 10000.0 | nM | - |