Assay Detail
Functional
CHEMBL950127
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Antiproliferative activity against human A549 cells after 3 days
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
New sulfurated derivatives of valproic acid with enhanced histone deacetylase inhibitory activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.12 | 4.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL402341 | — | — | 1 | 4.18 |
| CHEMBL272134 | — | — | 1 | 4.05 |
| CHEMBL271256 | — | — | 1 | - |
| CHEMBL271677 | — | — | 1 | - |
| CHEMBL271923 | — | — | 1 | - |
| CHEMBL255609 | — | — | 1 | - |
| CHEMBL109 | VALPROIC ACID | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL402341 | — | IC50 | = | 66000.0 | nM | 4.18 |
| CHEMBL272134 | — | IC50 | = | 89000.0 | nM | 4.05 |
| CHEMBL271256 | — | IC50 | = | 154000.0 | nM | - |
| CHEMBL271677 | — | IC50 | = | 154000.0 | nM | - |
| CHEMBL271923 | — | IC50 | = | 161000.0 | nM | - |
| CHEMBL255609 | — | IC50 | - | — | - | |
| CHEMBL109 | VALPROIC ACID | IC50 | > | 1000.0 | nM | - |