Assay Detail
Binding
CHEMBL950150
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Inhibition of HIV1 reverse transcriptase
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Investigation of the alkenyldiarylmethane non-nucleoside reverse transcriptase inhibitors as potential cAMP phosphodiesterase-4B2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.90 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL226735 | — | — | 1 | 7.70 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 7.08 |
| CHEMBL107200 | — | — | 1 | 6.52 |
| CHEMBL256906 | — | — | 1 | 6.30 |
| CHEMBL110359 | — | — | 1 | - |
| CHEMBL130984 | — | — | 1 | - |
| CHEMBL110175 | — | — | 1 | - |
| CHEMBL63 | ROLIPRAM | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL226735 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL57 | NEVIRAPINE | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL107200 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL256906 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL110359 | — | IC50 | - | — | - | |
| CHEMBL130984 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL110175 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL63 | ROLIPRAM | IC50 | - | — | - |