Assay Detail
Binding
CHEMBL950203
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Inhibition of CaMK2delta
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Calcium/calmodulin-dependent protein kinase type II subunit delta (CHEMBL2801) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Aryl-indolyl maleimides as inhibitors of CaMKIIdelta. Part 2: SAR of the amine tether.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 6.06 | 7.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL403446 | — | — | 1 | 7.47 |
| CHEMBL412302 | — | — | 1 | 6.75 |
| CHEMBL409856 | — | — | 1 | 6.52 |
| CHEMBL269264 | — | — | 1 | 6.51 |
| CHEMBL270875 | — | — | 1 | 6.42 |
| CHEMBL404077 | — | — | 1 | 6.35 |
| CHEMBL55788 | — | — | 1 | 6.19 |
| CHEMBL256452 | — | — | 1 | 6.06 |
| CHEMBL266487 | RO-316233 | — | 1 | 5.92 |
| CHEMBL256827 | — | — | 1 | 5.87 |
| CHEMBL403771 | — | — | 1 | 5.84 |
| CHEMBL300549 | — | — | 1 | 5.73 |
| CHEMBL218328 | — | — | 1 | 5.72 |
| CHEMBL446199 | — | — | 1 | 5.70 |
| CHEMBL404368 | — | — | 1 | 5.45 |
| CHEMBL256259 | — | — | 1 | 5.42 |
| CHEMBL411456 | — | — | 1 | 5.12 |
| CHEMBL404438 | — | — | 1 | - |
| CHEMBL380598 | — | — | 1 | - |
| CHEMBL54425 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL403446 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL412302 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL409856 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL269264 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL270875 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL404077 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL55788 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL256452 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL266487 | RO-316233 | IC50 | = | 1190.0 | nM | 5.92 |
| CHEMBL256827 | — | IC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL403771 | — | IC50 | = | 1450.0 | nM | 5.84 |
| CHEMBL300549 | — | IC50 | = | 1870.0 | nM | 5.73 |
| CHEMBL218328 | — | IC50 | = | 1890.0 | nM | 5.72 |
| CHEMBL446199 | — | IC50 | = | 2020.0 | nM | 5.70 |
| CHEMBL404368 | — | IC50 | = | 3530.0 | nM | 5.45 |
| CHEMBL256259 | — | IC50 | = | 3810.0 | nM | 5.42 |
| CHEMBL411456 | — | IC50 | = | 7540.0 | nM | 5.12 |
| CHEMBL404438 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL380598 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL54425 | — | IC50 | > | 20000.0 | nM | - |