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Assay Detail

CHEMBL950209

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Binding
Inhibition of CaMK2delta
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Publication

Aryl-indolyl maleimides as inhibitors of CaMKIIdelta. Part 3: Importance of the indole orientation.
Lu Q, Chen Z, Perumattam J, Wang DX, Liang W, Xu YJ, Do S, Bonaga L, Higaki J, Dong H, Liclican A, Sideris S, Laney M, Dugar S, Mavunkel B, Levy DE.
Bioorg Med Chem Lett (2008) 18 : 2399 -2403
PubMed 18337095 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 25 6.58 8.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL255607 1 8.00
CHEMBL402340 1 7.89
CHEMBL271648 1 7.68
CHEMBL402533 1 7.50
CHEMBL403337 1 7.42
CHEMBL270032 1 7.34
CHEMBL430412 1 6.96
CHEMBL411724 1 6.96
CHEMBL402152 1 6.82
CHEMBL271426 1 6.77
CHEMBL270141 1 6.72
CHEMBL271043 1 6.72
CHEMBL256460 1 6.55
CHEMBL271902 1 6.42
CHEMBL271254 1 6.42
CHEMBL270875 1 6.42
CHEMBL256872 1 6.25
CHEMBL270846 1 6.17
CHEMBL401681 1 6.13
CHEMBL271695 1 6.13
CHEMBL256265 1 6.12
CHEMBL270648 1 5.62
CHEMBL446110 1 5.34
CHEMBL403611 1 5.22
CHEMBL255117 1 4.93

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL255607 IC50 = 10.0 nM 8.00
CHEMBL402340 IC50 = 13.0 nM 7.89
CHEMBL271648 IC50 = 21.0 nM 7.68
CHEMBL402533 IC50 = 32.0 nM 7.50
CHEMBL403337 IC50 = 38.0 nM 7.42
CHEMBL270032 IC50 = 46.0 nM 7.34
CHEMBL430412 IC50 = 110.0 nM 6.96
CHEMBL411724 IC50 = 110.0 nM 6.96
CHEMBL402152 IC50 = 150.0 nM 6.82
CHEMBL271426 IC50 = 170.0 nM 6.77
CHEMBL270141 IC50 = 190.0 nM 6.72
CHEMBL271043 IC50 = 190.0 nM 6.72
CHEMBL256460 IC50 = 280.0 nM 6.55
CHEMBL271902 IC50 = 380.0 nM 6.42
CHEMBL271254 IC50 = 380.0 nM 6.42
CHEMBL270875 IC50 = 380.0 nM 6.42
CHEMBL256872 IC50 = 560.0 nM 6.25
CHEMBL270846 IC50 = 680.0 nM 6.17
CHEMBL401681 IC50 = 740.0 nM 6.13
CHEMBL271695 IC50 = 740.0 nM 6.13
CHEMBL256265 IC50 = 750.0 nM 6.12
CHEMBL270648 IC50 = 2410.0 nM 5.62
CHEMBL446110 IC50 = 4560.0 nM 5.34
CHEMBL403611 IC50 = 6000.0 nM 5.22
CHEMBL255117 IC50 = 11850.0 nM 4.93