Assay Detail
Binding
CHEMBL950331
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Inhibition of [3H]WIN-35428 uptake in human DAT transfected HEK293 cells
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent dopamine transporter (CHEMBL238) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
[4-(Phenoxy)pyridin-3-yl]methylamines: a new class of selective noradrenaline reuptake inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 21 | 5.66 | 6.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL440584 | — | — | 1 | 6.08 |
| CHEMBL401550 | — | — | 1 | 5.94 |
| CHEMBL404885 | — | — | 1 | 5.85 |
| CHEMBL270366 | — | — | 1 | 5.82 |
| CHEMBL403956 | — | — | 1 | 5.76 |
| CHEMBL273208 | — | — | 1 | 5.72 |
| CHEMBL405017 | — | — | 1 | 5.71 |
| CHEMBL258292 | — | — | 1 | 5.70 |
| CHEMBL401651 | — | — | 1 | 5.67 |
| CHEMBL429759 | — | — | 1 | 5.67 |
| CHEMBL258291 | — | — | 1 | 5.65 |
| CHEMBL261465 | — | — | 1 | 5.64 |
| CHEMBL408329 | — | — | 1 | 5.62 |
| CHEMBL270791 | — | — | 1 | 5.58 |
| CHEMBL436673 | — | — | 1 | 5.58 |
| CHEMBL403363 | — | — | 1 | 5.54 |
| CHEMBL265951 | — | — | 1 | 5.39 |
| CHEMBL403251 | — | — | 1 | 5.36 |
| CHEMBL262357 | — | — | 1 | 5.32 |
| CHEMBL14370 | REBOXETINE | 4.0 | 1 | - |
| CHEMBL256293 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL440584 | — | Ki | = | 834.0 | nM | 6.08 |
| CHEMBL401550 | — | Ki | = | 1160.0 | nM | 5.94 |
| CHEMBL404885 | — | Ki | = | 1410.0 | nM | 5.85 |
| CHEMBL270366 | — | Ki | = | 1520.0 | nM | 5.82 |
| CHEMBL403956 | — | Ki | = | 1750.0 | nM | 5.76 |
| CHEMBL273208 | — | Ki | = | 1910.0 | nM | 5.72 |
| CHEMBL405017 | — | Ki | = | 1930.0 | nM | 5.71 |
| CHEMBL258292 | — | Ki | = | 1980.0 | nM | 5.70 |
| CHEMBL401651 | — | Ki | = | 2130.0 | nM | 5.67 |
| CHEMBL429759 | — | Ki | = | 2150.0 | nM | 5.67 |
| CHEMBL258291 | — | Ki | = | 2250.0 | nM | 5.65 |
| CHEMBL261465 | — | Ki | = | 2280.0 | nM | 5.64 |
| CHEMBL408329 | — | Ki | = | 2390.0 | nM | 5.62 |
| CHEMBL270791 | — | Ki | = | 2640.0 | nM | 5.58 |
| CHEMBL436673 | — | Ki | = | 2660.0 | nM | 5.58 |
| CHEMBL403363 | — | Ki | = | 2880.0 | nM | 5.54 |
| CHEMBL265951 | — | Ki | = | 4060.0 | nM | 5.39 |
| CHEMBL403251 | — | Ki | = | 4350.0 | nM | 5.36 |
| CHEMBL262357 | — | Ki | = | 4800.0 | nM | 5.32 |
| CHEMBL14370 | REBOXETINE | Ki | > | 10000.0 | nM | - |
| CHEMBL256293 | — | Ki | - | — | - |