Assay Detail
Binding
CHEMBL950332
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]Nisoxetine uptake in human noradrenaline transporter transfected HEK293 cells
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent noradrenaline transporter (CHEMBL222) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
[4-(Phenoxy)pyridin-3-yl]methylamines: a new class of selective noradrenaline reuptake inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 21 | 7.00 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL14370 | REBOXETINE | 4.0 | 1 | 8.30 |
| CHEMBL270791 | — | — | 1 | 8.00 |
| CHEMBL273208 | — | — | 1 | 8.00 |
| CHEMBL403363 | — | — | 1 | 7.89 |
| CHEMBL256293 | — | — | 1 | 7.66 |
| CHEMBL436673 | — | — | 1 | 7.57 |
| CHEMBL405017 | — | — | 1 | 7.24 |
| CHEMBL403251 | — | — | 1 | 7.13 |
| CHEMBL401651 | — | — | 1 | 7.09 |
| CHEMBL401550 | — | — | 1 | 6.88 |
| CHEMBL258291 | — | — | 1 | 6.80 |
| CHEMBL429759 | — | — | 1 | 6.75 |
| CHEMBL404885 | — | — | 1 | 6.71 |
| CHEMBL403956 | — | — | 1 | 6.63 |
| CHEMBL440584 | — | — | 1 | 6.59 |
| CHEMBL265951 | — | — | 1 | 6.53 |
| CHEMBL261465 | — | — | 1 | 6.44 |
| CHEMBL258292 | — | — | 1 | 6.36 |
| CHEMBL408329 | — | — | 1 | 6.34 |
| CHEMBL262357 | — | — | 1 | 6.04 |
| CHEMBL270366 | — | — | 1 | 6.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL14370 | REBOXETINE | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL270791 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL273208 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL403363 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL256293 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL436673 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL405017 | — | Ki | = | 58.0 | nM | 7.24 |
| CHEMBL403251 | — | Ki | = | 74.0 | nM | 7.13 |
| CHEMBL401651 | — | Ki | = | 82.0 | nM | 7.09 |
| CHEMBL401550 | — | Ki | = | 131.0 | nM | 6.88 |
| CHEMBL258291 | — | Ki | = | 159.0 | nM | 6.80 |
| CHEMBL429759 | — | Ki | = | 179.0 | nM | 6.75 |
| CHEMBL404885 | — | Ki | = | 194.0 | nM | 6.71 |
| CHEMBL403956 | — | Ki | = | 232.0 | nM | 6.63 |
| CHEMBL440584 | — | Ki | = | 255.0 | nM | 6.59 |
| CHEMBL265951 | — | Ki | = | 296.0 | nM | 6.53 |
| CHEMBL261465 | — | Ki | = | 366.0 | nM | 6.44 |
| CHEMBL258292 | — | Ki | = | 438.0 | nM | 6.36 |
| CHEMBL408329 | — | Ki | = | 461.0 | nM | 6.34 |
| CHEMBL262357 | — | Ki | = | 921.0 | nM | 6.04 |
| CHEMBL270366 | — | Ki | = | 951.0 | nM | 6.02 |