Assay Detail
Binding
CHEMBL950348
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of mouse VEGFR2 autophosphorylation in NIH3T3 cell
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | NIH3T3 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL3337) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
TIE-2/VEGF-R2 SAR and in vitro activity of C3-acyl dihydroindazolo[5,4-a]pyrrolo[3,4-c]carbazole analogs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.00 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL444105 | — | — | 1 | 8.00 |
| CHEMBL269924 | — | — | 1 | 8.00 |
| CHEMBL271861 | — | — | 1 | - |
| CHEMBL401881 | — | — | 1 | - |
| CHEMBL403158 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL444105 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL269924 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL271861 | — | IC50 | > | 50.0 | nM | - |
| CHEMBL401881 | — | IC50 | < | 10.0 | nM | - |
| CHEMBL403158 | — | IC50 | < | 10.0 | nM | - |