Assay Detail
Binding
CHEMBL950411
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]flumazenil in rat GABAA alpha-1-beta-3-gamma-2 receptor expressed in HEK293 cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | HEK293 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
GABA-A receptor; alpha-1/beta-2/gamma-2 (CHEMBL2095167) ↗| Type | PROTEIN COMPLEX |
| Organism | Rattus norvegicus |
Publication
Azaflavones compared to flavones as ligands to the benzodiazepine binding site of brain GABA(A) receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 8.48 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL522061 | — | — | 1 | 9.10 |
| CHEMBL502159 | — | — | 1 | 8.92 |
| CHEMBL452728 | — | — | 1 | 7.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL522061 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL502159 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL452728 | — | Ki | = | 39.0 | nM | 7.41 |